Histopathological changes in livers of patients with chronic severe hepatitis B.
- Author:
Li-jie ZHANG
1
;
Tai-ling WANG
;
Xu-hua LIU
;
Ke-jia ZU
;
Xin MENG
;
Yue WANG
;
Zhong-ping DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Hepatitis B, Chronic; diagnosis; pathology; Humans; Liver; pathology; Male; Middle Aged; Staining and Labeling; Young Adult
- From: Chinese Journal of Hepatology 2007;15(5):323-325
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the histopathological features in livers of chronic severe hepatitis B (CSHB) patients.
METHODSHistology of 42 livers was studied. HE, Masson, Sweet and D-PAS staining and cytokeratin 7, CD68 and proliferating cell nuclear antigen immuno-histochemical staining were used in the study.
RESULTSIn CSHB, the livers showed massive or submassive necrosis in a background of other histological changes of chronic hepatitis B. The characteristic pictures of these livers were necrosis of all the hepatocytes in some nodules, while in other nodules there were only patchy necroses of the parenchyma. In some other nodules the necrotic hepatocytes were all removed and only the scaffolding stroma remained. Meanwhile, regeneration of hepatocytes and bile ductules were also seen.
CONCLUSIONSThe liver histopathological changes in CSHB are identical, but not of the same degree as those of acute severe and subacute severe hepatitis B. In making differential diagnoses for liver aspiration biopsies of these patients, this fact should be kept in mind.
