Liver pathology in idiopathic portal hypertension.
- Author:
Xia LIU
1
;
Tai-ling WANG
;
Can-hong XIANG
;
Xiang-xin PENG
;
Yue WANG
;
Nian CHEN
;
Min ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Fibrosis; pathology; Humans; Hypertension, Portal; pathology; Liver; pathology; Male; Middle Aged; Young Adult
- From: Chinese Journal of Hepatology 2007;15(5):374-377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the histopathological changes of livers in idiopathic portal hypertension (IPH).
METHODSLiver specimens from 29 cases with idiopathic portal hypertension were studied. Histological preparations of the livers were stained with haematoxylin eosin and Masson's trichrome; reticular fibers in the liver tissues were demonstrated. The slides were also stained using some immunohistochemistry methods, and the pathological changes of the livers were analyzed.
RESULTSThe characteristic changes found in these IPH livers were dense portal fibrosis; obliteration, with or without phlebitis, of the branches of the portal vein; dilatation of the sinusoids; atrophy and nodular hyperplasia of liver cells.
CONCLUSIONSHistopathological changes of the livers in IPH are dense portal fibrosis, portal vein branch obliteration and nodular hyperplasia of liver cells. These are the main features for a histopathological diagnosis of IPH.
