Clinical analysis of triple marker screening test for fetal Down syndrome in midtrimester of pregnancy-Low sensitivity of triple marker screening test.
- Author:
Kyoung Chul HAN
;
Dae Woon KIM
;
Su Mi JEONG
;
Won Kyu YANG
;
Chul Beom PARK
;
Bong Kyu SHIN
;
Jeong Hwan SHIN
;
Seo You HONG
- Publication Type:Original Article
- Keywords:
Triple serum marker;
Serum screen;
Pregnancy outcome;
Down syndrome
- MeSH:
Down Syndrome*;
Equidae;
Female;
Gestational Age;
Humans;
Mass Screening*;
Pregnancy;
Pregnancy Outcome;
Pregnancy Trimester, Second*;
Pregnant Women;
Retrospective Studies
- From:Korean Journal of Obstetrics and Gynecology
1999;42(9):1914-1918
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To assess the reliability of triple marker screening test in midtrimester pregnancy for fetal Down syndrome. METHODS: From October 1, 1996 to May 31, 1998 at Nowon Eulji Hospital, 3700 Pregnant women underwent serum tiple marker screening for Down syndrome during 15-20weeks of gestational age. The results of serum triple marker screenig tests for Down syndrome and the outcomes of pregnancies were retrospectively assesed. RESULTS: Sixty seven of 3700 cases(1.81%) were positive in screening test, and 3633(98.18%) cases were negative. Among 67 cases of positive screening test, 1 case(1.49%) was diagnosed as Down syndrome. Among 3633 cases of negative screening test, 4 cases(0.1%) were diagnosed as chromosomal abnormalies postnatally. Two of these 4 cases of chromosomal abnormalies were Down syndrome. CONCLUSION: With this results, sensitivity of triple marker screeing test for Down syndrome is very low as 33.3%. In order to increase the sensitivity, some compensatory adjustment is required in triple marker screening test.
