A Study of Altered Cell-Mediated Immunity in Peritoneal Fluid of Patients with Endometriosis.
- Author:
Jeong Bae KANG
;
Hyun Tae KIM
;
Hong Bae KIM
;
Keun Young LEE
;
Sung Won KANG
- Publication Type:Original Article
- Keywords:
Endometriosis;
Cell-mediated immune response
- MeSH:
Ascitic Fluid*;
Case-Control Studies;
Classification;
Endometriosis*;
Enzyme-Linked Immunosorbent Assay;
Female;
Fertility;
Genital Diseases, Female;
Humans;
Immunity, Cellular*;
Infertility;
Interleukin-6;
Laparotomy;
Outcome Assessment (Health Care);
Prospective Studies;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Obstetrics and Gynecology
1999;42(9):1965-1971
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-alpha in the peritoneal fluid(PF) of women with and without endometriosis and infertile women. Design: Prospective and case-control study. Setting: University hospital. Patients: Twenty-nine women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and twenty-eight women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Main Outcome Measures: PF IL-6 and tumor necrosis factor-alpha levels were determined using commercial ELISA. IL-6 and tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification. RESULTS: IL-6 and tumor necrosis factor-alpha concentrations were higher than in the PF of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in PF from patients with endometriosis: the concentrations in the secretory phase were significantly higher than those in the proliferative phase. IL-6 concentrations were higher than in the PF among of infertile women than in fertile women. A significant correlation between PF IL-6 and tumor necrosis factor-alpha concentrations and endometriosis stage III and IV was noted. CONCLUSIONS: Increased PF levels of IL-6 and tumor necrosis factor-alpha in patients with endometriosis may be relate to endometriosis-associated infertility and to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.
