Comparison of efficiencies mobilizing stem cells into peripheral blood in healthy donors by different schemes with G-CSF.
- Author:
Dan-Hong WANG
1
;
Mei GUO
;
Chang-Lin YU
;
Jian-Hui QIAO
;
Qi-Yun SUN
;
Shi ZHANG
;
Hui-Sheng AI
Author Information
1. Department of Hematology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Blood Cell Count;
Drug Administration Schedule;
Female;
Granulocyte Colony-Stimulating Factor;
administration & dosage;
Hematopoietic Stem Cell Mobilization;
Humans;
Male;
Middle Aged;
Peripheral Blood Stem Cell Transplantation;
methods;
Retrospective Studies;
Time Factors
- From:
Journal of Experimental Hematology
2007;15(1):165-167
- CountryChina
- Language:Chinese
-
Abstract:
The aim of study was to select the best scheme of G-CSF to mobilize peripheral stem/progenitor cells in healthy donors. The clinical data of 60 cases received nonmyeloablative allogenic hematopoietic stem cell transplantation was analyzed retrospectively. The results indicated that the counts of MNC and CD34(+) cells were significantly higher in the 10 microg/(kg.d) group than that in the 5 microg/(kg.d) group (P < 0.05). The counts of MNC and CD34(+) cells which were collected after day 4 or 5 in the 10 microg/(kg.d) groups were not significantly different. The percentage of CD3(+) cells, CD4(+) cells and CD8(+) cells were not different in different groups. It is concluded that the scheme using 10 microg/(kg.d) G-CSF is more efficient than that in the 5 microg/(kg.d) group in mobilizing stem cells. It may reduce days for mobilization and decrease expense for collection of cells after 4 days of mobilization. Scheme using 10 microg/(kg.d) G-CSF for cells collecting after 4 days is more efficient.
