Expression of the Human Erythrocyte Glucose Transporter (Glut-1) in Renal Cell Carcinoma.
- Author:
Cheol Su KIM
1
;
Sun Ju LEE
;
Youn Wha KIM
Author Information
1. Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea. sjlee@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Glucose transporter;
Immunohistochemistry;
Prognosis;
Renal cell carcinoma
- MeSH:
Carcinoma, Renal Cell*;
Cell Membrane;
Erythrocytes*;
Glucose Transport Proteins, Facilitative;
Glucose Transporter Type 1*;
Humans*;
Immunohistochemistry;
Kidney;
Nephrectomy;
Prognosis;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Urology
2001;42(12):1241-1245
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The objective of this work is to determine whether the degree of expression of Human Erythrocyte Glucose Transporter (Glut-1) protein might correlate with survival rate, tumor stage and pathologic findings in renal cell carcinoma (RCC). MATERIALS AND METHODS: 94 patients who underwent radical nephrectomy at our department for RCC were included in this retrospective study. Biologic significance of Glut-1 immunohistochemical staining according to the survival rate, tumor stage and pathologic findings in patients with RCC was evaluated. Immunohistochemical staining was performed using a primary antibody which was polyclonal rabbit anti-human Glut-1. RESULTS: In 67 of 94 patients, Glut-1 staining was demonstrated in the plasma membrane of cancer cells. Positive staining of Glut-1 in clear cell type was significantly higher than chromophobe type and chromophill type (p=0.01, 0.04). Positive staining for Glut-1 did not show any significant difference between localized and metastatic RCC. Positive staining for Glut-1 did not show any significant difference with tumor stage (p=0.09) or nuclear grade (p=0.20) or survival rate in localized RCC. CONCLUSIONS: In summary, Glut-1 protein express not in the normal portion of kidney but in the RCC. Expression of Glut-1 protein does not correlate with tumor stage, nuclear grade, or survival rate. These findings suggest that RCC may have another type of glucose transporter.
