The Prognostic Value of Tumor Angiogenesis, Hepatocyte Growth Factor and c-met Expression in Renal Cell Carcinoma.
- Author:
Hyun Jun PARK
1
;
Sang Don LEE
;
Moon Kee CHUNG
Author Information
1. Department of Urology, College of Medicine, Pusan National University, Busan, Korea. lsd@hyowon.pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatocyte growth factor;
Tumor angiogenesis;
Prognosis;
Renal cell carcinoma
- MeSH:
Angiogenesis Inducing Agents;
Antibodies;
Carcinoma, Renal Cell*;
Hepatocyte Growth Factor*;
Hepatocytes*;
Humans;
Immunohistochemistry;
Microvessels;
Prognosis
- From:Korean Journal of Urology
2001;42(12):1251-1257
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the prognostic significance of tumor angiogenesis and angiogenic factors such as hepatocyte growth factor (HGF) and c-met in renal cell carcinoma. MATERIALS AND METHODS: Immunohistochemical staining on HGF, c-met expression and angiogenesis was performed in 35 renal cell carcinoma tissues and 18 benign renal tissues. HGF and c-met were identified with specific corresponding antibodies. Cases were considered positive when HGF and c-met expression were seen in more than one third of cells. To evaluate the angiogenesis, the microvessels were determined by anti-CD31 immunohistochemistry. We compaired HGF, c-met and microvessel count with clinicopathologic characteristics such as stage, nuclear grade and histology in renal cell carcinoma. RESULTS: Among 35 patients with renal cell carcinoma, 16 patients (45.7%) showed positive stain for HGF and c-met. HGF, c-met overexpression and microvessel count were significantly correlated with tumor stage and nuclear grade of renal cell carcinoma (p<0.05), but not correlated with cell type of renal cell carcinoma. CONCLUSIONS: This results suggested that both HGF and c-met overexpression and angiogenesis measured by microvessels count could be significant prognostic indicators of renal cell carcinoma.
