Hepatocyte growth factor and its immunoregulatory activity - review.
- Author:
Li BIAN
1
;
Zi-Kuan GUO
;
Hui-Sheng AI
Author Information
1. Department of Hematology, The Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100039, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Graft Rejection;
immunology;
prevention & control;
Graft vs Host Disease;
immunology;
prevention & control;
Graft vs Leukemia Effect;
immunology;
Hepatocyte Growth Factor;
physiology;
Humans;
Immunity, Cellular;
immunology
- From:
Journal of Experimental Hematology
2007;15(2):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocyte growth factor (HGF) is a pleiotropic cytokine, its roles in the physiology and pathology of immune system, have been investigated thoroughly, great deal of data have been documented on its immunoregulatory activity. In this review, according to advance of study on HGF in recent years, the role of HGF in the immune regulation, such as immunoregulatory effects of HGF on T lymphocytes, B lymphocytes and dendritic cell, modulation of HGF on specific humoral and cellular immune response, control of acute GVHD and acceleration of myeloid and immunologic reconstitution in allogenetic bone marrow transplantation models, promotion of tissue repair and regeneration, and alleviation of immune rejection in allogeneic organ transplantation including the heart, liver and kidney transplantation, prevention of grafts from injury as well as applicably useful of HGF in the therapy of autoimmune disorders were summarized.
