Application of magnetic resonance DW imaging technique in studying treatment of cerebral ischemia in rats by single or combined use of jasminoidin and cholalic acid.
- Author:
Zhan-jun ZHANG
1
;
Zhong WANG
;
Peng-tao LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; drug therapy; Cholic Acids; therapeutic use; Diffusion Magnetic Resonance Imaging; methods; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Gardenia; chemistry; Iridoids; therapeutic use; Male; Neuroprotective Agents; therapeutic use; Phytotherapy; Pyrans; therapeutic use; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; prevention & control; Reproducibility of Results; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(4):332-336
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo estimate the therapeutic effect of single or combined use of jasminoidin and cholalic acid on focal cerebral ischemia rat with magnetic resonance-diffusion-weighted imaging (MR-DWI) technique, ultra-microscopy, and neuro-behavior scoring.
METHODSThe model of cerebral ischemia-reperfusion injury was induced by string method. Three hours after reperfusion, MR-DWI was applied with ultra-microscopy and neuro-behavior test to give evaluation on cerebral ischemic rats, and pathologic, ultramicroscopic observation of tissue were taken as adjuvant measures to comprehensively evaluate the pharmacological effect on ischemia-reperfusion rats and delimit the efficacy of the two different components and their combination.
RESULTSCompared with the model group, ADC and DCavg values of the foci in all the treated groups had the incrensing trend. There was significant difference arund the foci in the group of combined use of jasminoidin and cholalic acid (P < 0.05).
CONCLUSIONCombined use of jasminoidin and cholalic acid had protective effects on nerve and brain. MR-DWI technique accompanied with ultramicroscopic observation of tissues and neuro-behavior test is an effective method for evaluating the effect of neuro-protective agent.
