Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy.
- Author:
Su-min LI
1
;
Jing-xia YAN
;
Lin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Astragalus membranaceus; Benzazepines; therapeutic use; Dipyridamole; therapeutic use; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; Female; Glomerulonephritis, IGA; drug therapy; physiopathology; Humans; Injections, Intravenous; Kidney Tubules; physiopathology; Male; Middle Aged; Phytotherapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(6):504-507
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the renal tubular function and the severity of tubulo interstitial lesion and the effects of Astragalus Injection (AI) on renal tubular function in patients with IgA nephropathy (IgAN).
METHODSSixty-seven patients with IgAN were randomly divided into the control group and the astragalus group, both received dipyridamole and benazepril orally, while the astragalus group treated with AI by intravenous dripping additionally. The indices for renal tubular function, including protein in blood and urine, urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (UNAG), were detected. Area of glomerular Bowman capsule, renal tubules, and capillary were measured with color magic image analysis system type CMIAS2000.
RESULTSUrinary RBP and UNAG were correlated with tubulointerstitial lesion. Urine protein concentration decreased, blood albumin increased remarkably and renal tubular function improved after treatment in the astragalus group, with the improvement significantly different to those in the control group respectively.
CONCLUSIONThe severity of tubulointerstitial lesion was positively related to urinary RBP concentration, and astragalus injection has obvious effect on IgAN.
