Effect of xinnao shutong capsule on cardiac muscle cell apoptosis and protein expressions of Bcl-2 and Bax in hyperlipidemia rats after myocardial infarction.
- Author:
Yan GUO
1
;
Hui-jun YIN
;
Da-zhuo SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Capsules; Drugs, Chinese Herbal; therapeutic use; Hyperlipidemias; complications; drug therapy; Male; Myocardial Infarction; complications; drug therapy; Myocytes, Cardiac; metabolism; pathology; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; biosynthesis; genetics; Rats; Rats, Sprague-Dawley; bcl-2-Associated X Protein; biosynthesis; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(6):541-544
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Xinnao Shutong Capsule, whose main ingredients gross saponins from Tribulus Terrestris L (GSTT) on cardiac muscle cell (CMC) apoptosis and expressions of Bcl-2 Compound rat model of and Bax in murine model of hyperlipemia after myocardial infarction (MI).
METHODSMI and hyperlipemia was adopted. TUNEL assay was applied to detect CMC apoptosis after 4 weeks' administration of GSTT or simvastatin, and immunohistochemical SP technique was used to detect the expressions of Bcl-2 and Bax protein.
RESULTSGSTT can relieve the damage of CMC and attenuate the ventricular remodeling after MI; high dose of GSTT and simvastatin could decrease CMC apoptosis (P<0.05), and lower Bax protein expression (P < 0.05); and there was no significant difference among the effects in all the treated group (P> 0.05).
CONCLUSIONGSTT can reduce CMC apoptosis through regulating protein expressions of Bcl-2 and Bax, which may be one of the mechanisms of its anti-ventricular-remodeling effects after MI.
