Effects of tongxinluo on the myocardial inflammatory reaction and expression of tumor necrosis factor-alpha in rats with myocardial infarction.
- Author:
Qiang KONG
1
;
Xin-chun YANG
;
Xiu-lan LIU
Author Information
- Publication Type:Journal Article
- MeSH: Acute-Phase Reaction; Animals; Drugs, Chinese Herbal; therapeutic use; Male; Myocardial Infarction; complications; drug therapy; Myocarditis; etiology; metabolism; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; biosynthesis; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(6):545-549
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Tongxinluo (TXL) on myocardial inflammatory reaction and expression of tumor necrosis factor-alpha (TNF-alpha) in rats with myocardial infarction (MI).
METHODSThe rat MI model was established by left anterior descending coronary artery ligation. Experimental rats were randomly divided into 3 groups: the sham operated group, the MI control group and the TXL group (treated by 2.0 g/ kg/day). Conditions of inflammatory cellular infiltration in the infarcted and non-infarcted zone were observed at 1, 2 and 4 weeks after MI with histopathological methods, and the expression of TNF-alpha was detected by semi-quantitative RT-PCR and Western blot.
RESULTSObvious inflammatory cellular infiltration revealed in both infarcted and non-infarcted zone of model rats at 1-2 weeks after MI, it faded away gradually 4 weeks after MI, while the TNF-alpha expression increased continuously after MI. Compared with the MI control, the infiltration was milder and TNF-alpha expression was lower in the TXL group.
CONCLUSIONTXL displays its anti-inflammatory action by way of attenuating the myocardial inflammatory reaction and suppressing the expression of inflammatory cytokine TNF-alpha in MI rats.
