Analysis of the function of vascular endothelial cells in coronary heart disease patients of blood-stasis syndrome.
- Author:
Zhao-kai YUAN
1
;
Xian-ping HUANG
;
Guang-bo TAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Coronary Artery Disease; physiopathology; Diagnosis, Differential; Endothelial Cells; metabolism; physiology; Endothelins; metabolism; Female; Humans; Intercellular Adhesion Molecule-1; metabolism; Male; Medicine, Chinese Traditional; Middle Aged; Nitric Oxide; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(5):407-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the function of vascular endothelial cell (VEC) in patients with coronary heart disease (CHD) of Xin-blood-stasis syndrome.
METHODSSome vasoactive substances produced by VEC were detected and analyzed in patients with CHD of or without Xin blood stasis syndrome in group A (n=112) and group B (n=108) respectively, also in patients with non-CHD but of Xin-blood-stasis syndrome in group C (n=110), and healthy persons in group D (n=100), including nitric oxide (NO), endothelin (ET), angiotensin H (Ag II), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule -1 (sVCAM-1).
RESULTSThe abnormality degree of ET, Ag II , sICAM-1 and sVCAM-1 in various groups showed such a tendency as group A> group B> group D (P < 0.01 or P < 0.05), while no significant difference in these criteria between group A and group C was shown (P > 0.05).
CONCLUSIONThe vasoactive substances secreted by VEC are closely related to the formation and progression of CHD, and are likely to be important pathological markers of blood-stasis syndrome in CHD.
