Clinical observation on treatment of active systemic lupus erythematosus with haoqin qingdan decoction.
- Author:
Wei LIU
1
;
Hui WANG
;
Xiao-yan YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Complement C3; metabolism; Drug Administration Schedule; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; Female; Humans; Lupus Erythematosus, Systemic; drug therapy; Male; Middle Aged; Phytotherapy; Prednisone; administration & dosage
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(5):448-450
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutic efficacy and safety of Haoqin Qingdan Decoction (HQD) in treating active stage of systemic lupus erythematosus (SLE).
METHODSOne hundred and twenty patients with SLE were randomly assigned into two groups, the treated group receiving HQD and prednisone, and the control group receiving prednisone and cyclophosphamide (CTX), both were treated for 3 months. SLE disease activity index (SLEDAI), various immunological indexes, blood and urine routine, hepatic and renal function, as well as the other adverse reaction of the treatment were observed.
RESULTSThe total effective rate in the treated group was 81.67% (49/60), while 76.67% (46/60) in the control group, showing insignificant difference between the two groups. SLEDAI, erythrocyte sedimentation rate (ESR), complement 3 (C3), 24-hr urinary protein excretion and anti-double strain deoxyribonucleic acid (dsDNA) antibody were improved in the treated group, and no obvious adverse reaction was shown.
CONCLUSIONHQD is obviously more effective in treating active stage of SLE with high safety.
