Effect of donor-specific antibodies and panel reactive antibodies in living donor liver transplant recipients.
10.4174/astr.2015.88.2.100
- Author:
Seung Hwan SONG
1
;
Myoung Soo KIM
;
Jung Jun LEE
;
Man Ki JU
;
Jae Geun LEE
;
Juhan LEE
;
Jin Sub CHOI
;
Gi Hong CHOI
;
Soon Il KIM
;
Dong Jin JOO
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. djjoo@yuhs.ac
- Publication Type:Original Article
- Keywords:
Liver transplantation;
Donor specific antibody;
Acute rejection;
Graft survival;
Sensitization
- MeSH:
Adult;
Antibodies*;
Bile Ducts;
Cohort Studies;
Constriction, Pathologic;
Endothelium, Vascular;
Female;
Graft Survival;
HLA-A Antigens;
HLA-B Antigens;
HLA-DR Antigens;
Humans;
Incidence;
Liver Transplantation;
Liver*;
Living Donors*;
Male;
Retrospective Studies;
Transplantation*;
Transplants
- From:Annals of Surgical Treatment and Research
2015;88(2):100-105
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Preformed circulating donor-specific antibodies (DSAs) immunologically challenge vascular endothelium and the bile duct. However, the liver is an immune-tolerant organ and can avoid immunological challenges. This study was undertaken to analyze the effects of DSAs after adult living donor liver transplantation (LDLT). METHODS: We retrospectively reviewed 219 LDLT patients' records treated at our center. RESULTS: Of the 219 patients, 32 (14.6%) were DSA (+) and 187 (85.4%) were DSA (-). Class I DSAs were present in 18 patients, class II in seven patients, and both in seven patients. Seven patients (3.2%) showed DSA to HLA-A, four (1.8%) to HLA-B, seven (3.2%) to HLA-DR, and 14 (6.4%) to two or more HLAs. More DSAs were observed in female recipients than male recipients in the DSA (+) group. The DSA (+) group showed significantly higher levels of class I and II panel reactive antibody (PRA) than did the DSA (-) group. No significant intergroup differences were found between incidences of primary nonfunction, acute rejection, vascular complication, or biliary complication. There were no significant differences in graft survival rates between the two groups. However, the recipients with multiple DSAs tended to have more acute rejection episodes and events of biliary stricture and lower graft survival rates than did patients in the DSA (-) group. CONCLUSION: In LDLT, the presence of multiple DSAs and high PRA seemed to be associated with poor graft outcomes, although our results did not reach statistical significance. Large cohort studies are necessary to clarify the impact of DSA and PRA in LDLT.
