Advancements in expression of vascular endothelial growth factor receptors in skin diseases.
- Author:
Xiao-Hong YANG
1
;
Xiao-Yong MAN
;
Min ZHENG
Author Information
1. Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Receptors, Vascular Endothelial Growth Factor;
biosynthesis;
Signal Transduction;
Skin Diseases;
metabolism;
Vascular Endothelial Growth Factor A;
physiology
- From:
Acta Academiae Medicinae Sinicae
2007;29(2):279-282
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor (VEGF) exerts its biological functions by its specific VEGF receptors (VEGFR), which includes VEGFR-1, VEGFR-2, VEGFR-3, neuropilin-1, and neuropilin-2. These VEGFR distributes in endothelial cells, and are also expressed in normal skin, inflammatory skin diseases, and skin cancers. The VEGF-VEGFR signaling pathway may be a new key target in the management of the skin diseases.
