Roles of microRNAs in hematopoietic cell differentiation and the related tumors.
- Author:
Gui-hua YANG
1
;
Fang WANG
;
Jun-wu ZHANG
Author Information
1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
- Publication Type:Journal Article
- MeSH:
Blood Cells;
physiology;
Cell Differentiation;
Hematologic Neoplasms;
pathology;
Hematopoiesis;
physiology;
Humans;
MicroRNAs;
physiology
- From:
Acta Academiae Medicinae Sinicae
2007;29(3):425-429
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a family of 21-25 nucleotide small nonprotein-coding RNAs. They regulate gene expression at post-transcriptional level by mRNA degradation or translation repression. Hematopoiesis is one of the most important highly regulated multistage process, which includes orderly turn-on and turn-off of many genes; any wrong modulation may result in blood diseases. Several miRNAs have been found to be involved in hematopoiesis and hematopoietic tumor genesis.
