Relationship of myeloid differentiation-2 gene promoter polymorphisms with susceptivity of complications after severe trauma in Chinese Han population.
- Author:
Wei GU
1
;
You-an SHAN
;
Qing LIU
;
Jian ZHOU
;
Dong-po JIANG
;
Yuan-zhang YAO
;
Lian-yang ZHANG
;
Ding-yuan DU
;
Jin-mou GAO
;
Hong DONG
;
Ce YANG
;
Pei-fang ZHU
;
Zheng-guo WANG
;
Jian-xin JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; China; Genetic Predisposition to Disease; Humans; Lymphocyte Antigen 96; genetics; Multiple Organ Failure; etiology; genetics; Polymorphism, Genetic; Promoter Regions, Genetic; Sepsis; etiology; genetics; Wounds and Injuries; complications; genetics
- From: Acta Academiae Medicinae Sinicae 2007;29(4):484-487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphisms of myeloid differentiation-2 (MD-2) gene promoters, and to explore whether such polymorphisms are associated with the susceptibility to multiple organ dysfunction syndrome (MODS) and sepsis in Chinese Han population.
METHODSUsing polymerase chain reaction-restriction fragment length polymorphism method, the authors detected the single nucleotide polymorphisms of the promoter region of MD-2 gene at position - 1625C/G in 105 severe trauma patients (42 with sepsis). The organ function was scored.
RESULTSThe frequency of CC genotype in MD-2 gene promoter region at position - 1625 was 0.5 (21/42) in septic patients and 0.7 (44/63) in non-septic patients. The frequency of CG genotype was 0.38 (16/42) in septic patients and 0.27 (17/63) in non-septic patients. The frequency of GG genotype was 0.12 (5/42) in septic patients and 0.03 (2/63) in non-septic patients. The MODS scores in trauma patients carrying G allele at position - 1625 were significantly higher than those carrying C allele (P<0.001 for dominant effect, and P>0.05 for recessive effect). Moreover, trauma patients carrying G allele appeared to have higher risk of sepsis comparing to those carrying C allele (OR 0.477, 95% CI 0.266-0.855, P<0.05). Sepsis morbidity was significantly different between subjects with C and G alleles (P<0.05 for dominant effect, P>0.05 for recessive effect).
CONCLUSIONSThe polymorphisms of the promoter region of MD-2 gene at position - 1625 C/G is correlated with MODS and sepsis after severe trauma in Chinese Han population. The people with - 1625 G allele in the promoter region of MD-2 gene may be a risk factor of severe complications.