Association of APOA5 gene polymorphism with levels of lipids and atherosclerotic cerebral infarction in Chinese.
- Author:
Jie LI
1
;
Hong-wei XU
;
Xiao-yan ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Apolipoprotein A-V; Apolipoproteins A; genetics; Asian Continental Ancestry Group; genetics; Case-Control Studies; Cerebral Infarction; blood; complications; genetics; Female; Gene Frequency; Genotype; Humans; Intracranial Arteriosclerosis; blood; complications; genetics; Lipids; blood; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2007;24(5):576-578
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the polymorphism of apolipoprotein A5 gene (APOA5) -12238 T>C and atherosclerotic cerebral infarction (ACI).
METHODSThree hundred and forty-one subjects (170 ACI patients and 171 healthy controls) were collected to determine the genotypes by using polymerase chain reaction-restriction fragment length polymorphisms.
RESULTSAPOA5 allele frequencies of T/C were 0.588/0.412 and 0.424/0.576 in ACI group and control group respectively. There was significant difference in allele and genotype frequencies between ACI group and control group (P < 0.05). The levels of plasma triglyceride in ACI patients with TT genotype were higher than those in patients with CC genotypes (P < 0.05).
CONCLUSIONThe relationship is found between the site of APOA5 gene -12238 T>C and ACI. There is a significant correlation between TT genotype of APOA5 and the levels of plasma triglyceride in patients with ACI.
