Microsatellite DNA polymorphism of adrenomedullin gene and atherosclerotic cerebral infarction.
- Author:
Guo-rong BI
1
;
Hong HAI
;
Li-juan BAI
;
He-min ZHANG
;
Hui-jie ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adrenomedullin; genetics; Adult; Aged; Alleles; Case-Control Studies; Cerebral Infarction; complications; genetics; Female; Gene Frequency; Genotype; Humans; Intracranial Arteriosclerosis; complications; genetics; Male; Microsatellite Repeats; genetics; Middle Aged; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2007;24(5):579-581
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the correlation between the microsatellite DNA polymorphism of adrenomedullin(ADM) gene (repeated sequences of CA) and the atherosclerotic cerebral infarction (ACI).
METHODSWith PCR, ADM genotype was monitored from 189 normotensive subjects and 283 cerebral infarction patients. By using radioimmunoassay, their plasma ADM concentration was measured, so as the biochemical index.
RESULTSThe genotype distribution of ADM between the health control and ACI groups was significantly different, chi square was 28.732, P < 0.05. As one of the four alleles, including 11, 13, 14 and 19 alleles, the frequency of 19 allele in ACI groups was much higher than that in the health control group, chi square was 26.929, P < 0.05. However, there was no significant difference in plasma ADM concentration among the different genotypes of the ACI patients.
CONCLUSIONMicrosatellite DNA polymorphism of ADM gene may be associated with the genetic predisposition to ACI.
