Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population.
- Author:
Jian LIU
1
;
Miao LI
;
Man-long QI
;
Xiao-liang LIU
;
Ying-hui LI
;
Ling-yu FU
;
Yan-yan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; Base Sequence; Case-Control Studies; Ethnic Groups; genetics; Female; Gene Frequency; Genotype; Glutathione Transferase; genetics; Humans; Hypertension; genetics; pathology; Isoenzymes; genetics; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; genetics; Regression Analysis
- From: Chinese Journal of Medical Genetics 2007;24(5):582-585
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension (EH).
METHODS-63A/C polymorphism of GSTM3 gene was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 234 patients with EH and 328 healthy controls. The genotypes were confirmed partially by DNA sequencing.
RESULTSThe distribution of GSTM3 -63A/C was in Hardy-Weinberg equilibrium. The CC genotype frequency in EH group (6%) was significantly higher than that in control group(1.8%) (P < 0.05). After adjustment for age, body mass index, and other risk factors, the CC genotype was independently associated with hypertension (OR=3.447, 95%CI: 1.19-7.63; P=0.04).
CONCLUSIONThe GSTM3 -63A/C polymorphism was associated with EH in Chinese Han population, the C allele might be a risk factor for EH in Chinese Han nationality.
