Polymorphism of the human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population.
- Author:
Hui HUANG
1
;
Ming-liang FENG
;
Tong SHEN
;
Wei SHEN
;
Biao YIN
;
Da-zhuang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Antigens, Human Platelet; genetics; immunology; Asian Continental Ancestry Group; genetics; China; ethnology; DNA; genetics; Ethnic Groups; genetics; Gene Frequency; Genotype; Histocompatibility; genetics; Humans; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2007;24(5):586-588
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the polymorphism of human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population.
METHODSA total of 1000 unrelated Chinese Han blood donors from different provinces of China were genotyped for HPA-3 and HPA-9w using PCR-sequence specific primer assay.
RESULTSGene frequencies of 1000 Chinese Hans for HPA-3a and HPA-3b were 0.5935 and 0.4065 respectively, and all of them were HPA-9a positive. The distributions of HPA-3, HPA-9w of Chinese Hans which detected by chi-square criterion fit Hardy-Weinberg equilibrium. There were significant differences of the HPA-3 alleles gene frequency between Guangdong province and other five investigated provinces which included Shanxi, Heilongjiang, Zhejiang, Yunnan and Jiangsu. In comparison to other ethnic groups, no significant differences were observed in the distributions of HPA-3 except the Vietnamese and Australian.
CONCLUSIONThe results show that the chance of HPA-3 incompatibility were 0.3661 in random transfusion, and also provide a basis for researching on alloimmune thrombocytopenia and HPA-matched transfusion.
