Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in ethnic minority from Guizhou.
- Author:
Wei ZHANG
1
;
Ke-ren SHAN
;
Chang-xue WU
;
Yi LI
;
Yan XIAO
;
Yan ZHAO
;
Xiao-lan QI
;
Yuan XIE
;
Yan HE
;
Ran GU
;
Zhi-zhong GUAN
;
Xi-lin REN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; China; ethnology; Ethnic Groups; genetics; Female; Gene Frequency; genetics; Genotype; Glutathione S-Transferase pi; genetics; Glutathione Transferase; genetics; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2007;24(5):589-591
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in Dong, Yi and Yao ethnic groups from Guizhou.
METHODSIn 321 volunteers who were population-based, GSTM1 and GSTT1 polymorphisms were analyzed by a multiplex-PCR procedure, whereas GSTP1 polymorphism was analyzed by PCR-RFLP method.
RESULTSNull genotype for GSTM1 and GSTT1 was 59.6%-71.2% and 39.4%-72.5%, respectively. The genotypic distribution of GSTP1 was 63.3%-75% for AA, 23.2%-35.8% for AG, 0-1.9% for GG, whereas the allelic frequencies were 81.2%-86.6% for the A allele, and 13.4%-18.8% for the G allele.
CONCLUSIONThere is a significant relationship between GSTT1 frequencies and ethnic populations.
