Genetic polymorphism of twelve Y chromosomal short tandem repeat loci in Chinese Hui ethnic group.
- Author:
Yong-sheng ZHU
1
;
Zheng-hao HUO
;
Bing YU
;
Hong-bo ZHANG
;
Yu-jiong WANG
;
Wei ZHAO
;
Hai-yan JIAO
;
Jie DANG
;
Sheng-bin LI
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; ethnology; Chromosomes, Human, Y; genetics; Ethnic Groups; genetics; Gene Frequency; Haplotypes; Humans; Male; Microsatellite Repeats; genetics; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2007;24(5):594-597
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo obtain the genetic polymorphism of Y chromosomal short tandem repeat (Y-STR) loci in Ningxia Hui population.
METHODSBlood samples were collected from 150 unrelated healthy male individuals of Ningxia Hui ethnic group. Twelve Y-STR loci were amplified in one tube by using the PowerPlex System STR Amplification Kit, and the genotypes were determined using Genescan and Genotype software of ABI377 DNA sequencer and the frequency of alleles and haplotypes of Ningxia Hui ethnic was obtained.
RESULTSSeventy-five alleles were observed at 12 Y-STR loci. The frequency ranged from 0.0067-0.7067 and the gene diversity ranged from 0.4446-0.8877. Totally 148 different haplotypes were found, which were unique in 150 males. Two haplotypes were shared by 2 males respectively. The haplotype diversity was 0.9864.
CONCLUSIONThe 12 Y-STR loci are highly polymorphic in Ningxia Hui population and are suitable for genetics and forensic research.
