Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees.
- Author:
Xue-ji WU
1
;
Lei QIN
;
Jin-yi ZHOU
;
Jin-luo CHENG
;
Mo-yu SHEN
;
Jin-song WANG
;
Ling ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Diabetes Mellitus, Type 2; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Insulin Resistance; Male; Middle Aged; Pedigree; Polymorphism, Genetic; Urotensins; genetics
- From: Chinese Journal of Medical Genetics 2007;24(6):656-659
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees.
METHODSPatients and controls with/without familial history were enrolled in the same place.
RESULTSCarriers with AG or AA genotype from pedigrees had higher disease risk than those with GG genotype (OR=1.98, 95% CI:1.19-3.29,OR=2.46,95% CI:1.39-4.34), the frequency of A allele was higher in the patients from pedigrees than inner controls and patients who had no familial history (P=0.01). The frequency of A allele was higher in the inner controls than outer ones (P=0.001). The insulin resistance index, insulin sensitivity index and pancreatic secretion index of inner controls with AG genotype were higher than those with GG genotype (All P < 0.05).
CONCLUSIONThis polymorphism of UT-II gene might be a risk to type 2 diabetes, the insulin function of people from pedigrees is associated with the mutation.
