Clinical and laboratory investigation of hematological malignancy patients carrying 3q21q26 rearrangement.
- Author:
Fang-yun XU
1
;
Xu-ping LIU
;
Shuang QIN
;
Cheng-wen LI
;
Dong LIN
;
Ying-chang MI
;
Shi-he LIU
;
Jian-xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Inversion; Chromosome Mapping; Chromosomes, Human, Pair 3; genetics; Female; Gene Rearrangement; Hematologic Neoplasms; genetics; pathology; Humans; Karyotyping; Leukemia; genetics; Male; Middle Aged; Myelodysplastic Syndromes; genetics; pathology; Translocation, Genetic
- From: Chinese Journal of Medical Genetics 2007;24(6):696-698
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and laboratory characteristics of various hematopoietic malignant patients with t(3;3)(q21;q26) or inv(3) (q21q26).
METHODSBone marrow samples were collected at presentation, prepared by short-time unstimulated culture and R-binding, and karyotyped by conventional cytogenetical assay (CCA); megalokaryocytes were detected by Streptavidin-AKP (SAP); immunotype of the leukemia cells was tested by flow cytometric anylysis of surface antigens (FACS).
RESULTSAll of the 9 hematopoietic malignant patients with t(3;3)(q21;q26) or inv(3) (q21q26) manifested myelodysplasia and poor treatment response. One of them relapsed shortly after allogenic hemotopoietic stem cell transplantation (allo-HSCT).
CONCLUSIONPatients with 3q21q26 rearrangement can be found in various hematopoietic malignances and demonstrate an unique entity. These patients show poor treatment response and have extremely poor prognosis.
