Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension.
- Author:
Yi-yang ZHAN
1
;
Xiao JIANG
;
Gang LIN
;
Jian LI
;
Hai-hui SHENG
;
Hua-sheng XIAO
;
Yun-lin CHENG
;
Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Hypertension; epidemiology; genetics; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Drug; genetics; Risk; Sodium Chloride Symporters; genetics
- From: Chinese Journal of Medical Genetics 2007;24(6):703-705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of thiazide-sensitive Na+ -Cl* cotransporter (TSC) gene 1784C/T and 2736G/A polymorphisms with the risk of essential hypertension (EH) in a Han nationality population.
METHODSA community-based, case-control study including 190 EH patients and 94 sex- and age-matched controls was conducted. Genotypes of TSC gene 1784C/T and 2736G/A polymorphisms were analyzed by gene chip technology.
RESULTSThe genotype (1784C/T CC, CT, TT:87, 88, 15 vs 36, 52, 6û2736G/A GG, AG, AA:167, 22, 1 vs 83, 10, 1) and alleles frequency (1784C/T C, T:68.9%, 31.1% vs 66.0%, 34.0%; 2736G/A G,A:93.7%, 6.3% vs 93.6%, 6.4%) distribution of 1784C/T and 2736G/A showed no significant difference between the EH group and the control group (P >0.05). Moreover, no significant difference was observed in the frequencies distribution of four haplotypes (P > 0.05); Logistic regression analysis of haplotypes showed that the risk of EH had no significant difference in the population with different haplotypes (P > 0.05).
CONCLUSIONThe 1784C/T and 2736G/A polymorphisms of TSC gene may not play an important role in the etiology of EH in a Han nationality population. The studies in the future are warranted to validate our findings.
