Genetic polymorphism of four X chromosome short temden repeats loci in Hebei Han population.
- Author:
Yi WANG
1
;
Xue BAI
;
Bin CONG
;
Shu-jin LI
;
Li-hong FU
;
Chun-ling MA
;
Yan-mei ZHAO
;
Lei ZHANG
;
Yan-feng ZHEN
;
Yu-xia YAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Chromosomes, Human, X; Female; Genetics, Population; Humans; Male; Polymorphism, Genetic; Tandem Repeat Sequences; genetics
- From: Chinese Journal of Medical Genetics 2007;24(6):713-716
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphism of loci DXS6800, DXS6797, GATA172D05, DXS986 four loci in Hebei Han population.
METHODSThe genome DNA of unrelated individuals,the families and rotten materials were extracted with phenol-chloroform method and Chelex-100 method,respectively. The PCR products were detected by the polyacrylamide gel electrophoresis and DNA sequencing analysis.
RESULTSAmong 150 unrelated males and 150 unrelated females from Hebei Han population, 25 alleles were found in the 4 loci. One hundred and thirty-eight haplotypes of the male were detected. The haplotype diversity reached 0.9986.
CONCLUSIONThe findings provided the polymorphic data of DXS6800, DXS6797, GATA172D05, and DXS986 loci in Hebei Han population. The four loci are relatively abundant in polymorphic information for identification and the obtained data of Hebei Han population can be applied to the X-STR genetic data bank.