Study on the association of -689C/T polymorphism in the PPARgamma2 promoter with myocardial infarction.
- Author:
Jian-ping LI
1
;
Long-xian CHENG
;
Mei-an HE
;
Tang-chun WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Case-Control Studies; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; genetics; PPAR gamma; genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; genetics; Risk Factors
- From: Chinese Journal of Medical Genetics 2008;25(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of -689C/T polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) promoter with myocardial infarction (MI).
METHODSThis is a case-control study, which included 194 subjects with MI and 693 subjects without MI in nondiabetic Han population in Wuhan. Polymerase chain reaction-restriction fragment length polymorphism was used to determine the -689C-->T substitution.
RESULTSThe CC,CT, and TT genotype frequencies of -689C/T polymorphism were 88.1%,11.9%,and 0.0 in MI patients and 93.1%,6.6%,and 0.3% in controls, respectively (CC vs. CT+TT, P=0.025). The -689T allele was an independent risk factor for MI (OR=2.125, 95%CI: 1.206-3.744, P=0.009) after adjusting for age,sex,waist circumference,body mass index, smoking, alcohol drinking, physical activities, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, level. The -689T allele carriers had significantly higher TC levels than noncarriers [(5.05+/-1.16) mmol/L vs. (4.78+/-1.05) mmol/L, P=0.004] in the total population.
CONCLUSIONThe PPARgamma2 promoter -689C/T polymorphism is associated with an increased risk of MI.
