Evaluating the applicability of MoM in second trimester maternal serum to screening for Down's syndrome in Jiangsu province.
- Author:
Bi-yun XU
1
;
Yali HU
;
Chun-yan ZHANG
;
Jian-wei ZHANG
;
Qi-lan LIU
;
Hui YUE
;
Tong RU
;
Zheng-feng XU
;
Rui-fang ZHU
;
Ying ZHANG
;
Xiaoling ZHONG
;
Qing-mei WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Body Weight; China; Chorionic Gonadotropin; blood; Down Syndrome; diagnosis; Female; Fetal Diseases; diagnosis; Gestational Age; Humans; Middle Aged; Mothers; Pregnancy; Pregnancy Trimester, Second; blood; Prenatal Diagnosis; methods; Reference Values; Regression Analysis; Software; alpha-Fetoproteins; metabolism
- From: Chinese Journal of Medical Genetics 2008;25(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the applicability of MultiCalc software to prenatal screening of Down's syndrome in Jiangsu province, China.
METHODSThe gestational age-specific median of maternal serum marker was calculated by means of regression method. Regression functions for adjustment of Multiple of the Median (MoM) by weight were established for our own population.
RESULTSBefore the adjustment by weight, the average level of alpha fetal protein(AFP) was 16% higher and the free beta-human chorionic gonadotrophin (beta-hCG) was 14% higher than those of the Caucasian in MultiCalc software respectively. But when the AFP and free beta-hCG results were converted to weight-adjusted MoM levels, the values were 0.99 and 1.02 respectively. The median of MoM of AFP and the free beta-hCG were 1.00 through the regression model of gestational age and weight adjustment.
CONCLUSIONThere was no difference of average weight-adjusted MoM levels between the Jiangsu population and the Caucasian, and the MultiCalc software was applicable to maternal serum screening for Down's syndrome of Jiangsu.
