Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy.

Author: Xiaoli WANG ¹ ; Li ZHANG ; Rong-qing OU ; Jing WANG ; Shu-yun LIU ; Qiang CHEN ; Pin-can SU
Author Information

1. Department of Obstetrics and Gynecology, the Second People's Hospital of Chengdu, Chengdu, Sichuan, 610017 People's Republic of China.
Publication Type:Journal Article
MeSH: Case-Control Studies; Cholestasis, Intrahepatic; genetics; Cytochrome P-450 CYP1A1; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; genetics
From: Chinese Journal of Medical Genetics 2008;25(1):70-72
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.
METHODSMspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.
RESULTSThere was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).
CONCLUSIONThe Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu.