Calculation of paternity index for paternity testing with considering mutation.

Author: Yi-ping HOU ¹ ; Jin WU ; Jin YAN
Author Information

1. Department of Forensic Genetics, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. forensic@scu.edu.cn
Publication Type:Journal Article
MeSH: Female; Humans; Male; Microsatellite Repeats; genetics; Mutation; Paternity
From: Chinese Journal of Medical Genetics 2008;25(2):176-178
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo formulate recommendations in calculation of paternity index in paternity testing under considering mutations.
METHODSDifferent formulas under considering mutations were developed according to Brenner method.
RESULTSDifferent formulas under considering mutations were obtained. Both true exclusion and false exclusion of paternity were easily distinguished using these formulas when the genetic pattern was inconsistent with paternity.
CONCLUSIONThe scientific evidence for paternity testing can be obtained using these formulas under considering mutations when both the combined probability of exclusion and the paternity index meet the threshold values. However, when either the combined probability of exclusion or the paternity index can not meet the threshold values, more genetic markers should be added.