Association of the XRCC1 and hOGG1 polymorphisms with the risk of laryngeal carcinoma.
- Author:
Yuan YANG
1
;
He TIAN
;
Zhi-jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Carcinoma; genetics; DNA Glycosylases; genetics; DNA-Binding Proteins; genetics; Female; Genetic Predisposition to Disease; genetics; Humans; Laryngeal Neoplasms; genetics; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; X-ray Repair Cross Complementing Protein 1
- From: Chinese Journal of Medical Genetics 2008;25(2):211-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the association between the polymorphisms of X-ray repair cross complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase I (hOGG1) gene and the risk for laryngeal carcinoma.
METHODSThis is a case-control study comprised of two groups: 72 patients with laryngeal squamous carcinoma, and 72 controls without laryngeal carcinoma. The PCR-restriction fragment length polymorphism method was used to analyze the XRCC1-Arg399Gln, hOGG1-Ser326Cys polymorphisms.
RESULTSThe frequencies of XRCC1-399Arg/Gln+ Gln/Gln and hOGG1-326Ser/Cys+ Cys/Cys genotypes in the case group were higher than that of the control group(P< 0.05). There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively. No statistically significant differences were found between the smoking group and non-smoking group for risk of laryngeal carcinoma.
CONCLUSIONThe amino acid replacement of XRCC1-399Arg to Gln and hOGG1-326Ser to Cys might lead to an increased risk of laryngeal carcinoma. The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.
