Association of the Thr241Met polymorphism of DNA repair gene XRCC3 with genetic susceptibility to AFB1-related hepatocellular carcinoma in Guangxi population.
- Author:
Xi-dai LONG
1
;
Yun MA
;
Zhuo-lin DENG
;
Yong-zhi HUANG
;
Ni-bo WEI
Author Information
- Publication Type:Journal Article
- MeSH: Aflatoxin B1; toxicity; Carcinoma, Hepatocellular; chemically induced; genetics; Case-Control Studies; China; DNA-Binding Proteins; genetics; Genetic Predisposition to Disease; genetics; Genotype; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; genetics
- From:Chinese Journal of Medical Genetics 2008;25(3):268-271
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association of the Thr241Met polymorphism of X-ray cross-complementing group 3 (XRCC3) gene with genetic susceptibility to aflatoxin B1(AFB-1)-related hepatocellular carcinoma (HCC)in Guangxi population.
METHODSWe conducted a hospital-based case-control study, including 257 HCC cases and 711 controls without cancers or liver diseases. The XRCC3 Thr241Met polymorphism was analyzed by PCR.
RESULTSThe XRCC3 genotypes XRCC3-Thr/Met or XRCC3-Met/Met were related with an elevated risk of HCC. The risk of HCC was associated with the number of mutant Met copies (adjusted OR were 2.20 and 8.56 for XRCC3-Thr/Met and Met/Met, respectively); moreover, there seemed to be combined effects for HCC risk between the variant genotypes and AFB1-DNA adduct levels from peripheral blood leukocytes (adjusted OR was 2.34 to 20.44, P < 0.01).
CONCLUSIONThese results suggested that XRCC3 polymorphism may be associated with the risk of AFB1- related HCC among the Guangxi population, and interacts with AFB1 exposure in the development of HCC induced by AFB1.
