Association of two polymorphisms in ubiquitin carboxy-terminal hydrolase-L1 gene with Parkinson's disease in Shanghai.
- Author:
Yi-xin HAO
1
;
Jun ZHANG
;
Chao-ping FANG
;
Qian ZHANG
;
Jian-rong ZHANG
;
Qian SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; China; Exons; genetics; Female; Gene Frequency; genetics; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Middle Aged; Parkinson Disease; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; genetics; Ubiquitin Thiolesterase; genetics
- From:Chinese Journal of Medical Genetics 2008;25(3):272-275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship of polymorphisms in the ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) gene with Parkinson's disease(PD)in Shanghai Han Nationality.
METHODSThe distribution of a Serine18Tyrosine polymorphism in exon 3(C/A) and a Serine89Phenylalanine polymorphism in exon 4(C/T)of UCH-L1 gene were detected in 164 PD cases and 172 healthy controls, using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method.
RESULTS(1)The C allelic frequency in exon 3 of UCH-L1 gene in PD patients(62.2%) was significantly higher than that of the healthy controls(51.7%) (OR=1.53, P=0.006), as was the C/C genotype(OR=1.90, P=0.008). (2)There was no significant difference in the distribution of the C/T allele and genotypes in exon 4 between PD patients and healthy controls.
CONCLUSIONThe C allele in exon 3 of UCH-L1 gene might be one of the risk factors for PD in Shanghai Han Nationality, but the polymorphisms of C/T in exon 4 showed no association with the onset of PD.
