The associated study on apolipoprotein A5 gene polymorphisms with carotid artherosclerosis in patients with cerebral infartion.
- Author:
Kui ZHANG
1
;
Fang QIU
;
Lei LI
;
Guang-yu GU
;
Yue TAO
;
Li WANG
;
Xun-yang LUO
;
Yong-quan XIA
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Apolipoproteins A; genetics; Carotid Artery Diseases; complications; genetics; Cerebral Infarction; complications; genetics; Female; Genetic Predisposition to Disease; genetics; Haplotypes; genetics; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2008;25(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of -1131T>C and c.553G>T polymorphisms and their haplotypes in apolipoprotein A5(ApoA5) gene with cereberovascular disease in Chinese.
METHODSUsing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), we analyzed two ApoA5 genetic variants in 272 patients with cerebral infarction (CI) and 316 control individuals respectively. The levels of serum lipid profiles were measured with biochemical methodsìand the other clinical characters were obtained by case file investigation.
RESULTSThe odds ratio (OR) for CI in -1131CC genotype carriers was 2.10 (95%CI 1.01-4.37). The distribution of T-T and T-G haplotypes had obvious differences between CI patients and control individuals. The OR for CI in C-G and T-G haplotype carriers were 1.34 and 0.71(95% CI 1.02-1.76 and 0.55-0.92) respectively, compared with the others. Furthermore, the major haplotypes had significant differences of serum TG(P< 0.05).
CONCLUSIONThe ApoA5 -1131T>C polymorphism may be associated with an increased risk of CI in the Chinese population, but the influence of blood lipids can not be ignored.
