Changes of tumor necrosis factor, surfactant protein A, and phospholipids in bronchoalveolar lavage fluid in the development and progression of coal workers' pneumoconiosis.
- Author:
Jing-Cai XING
1
;
Wei-Hong CHEN
;
Wen-Hui HAN
;
Mei-Feng GUO
;
Steffeni REHN
;
Joachim BRUCH
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Animals; Biomarkers; analysis; Bronchoalveolar Lavage Fluid; chemistry; Coal Mining; Disease Progression; Humans; L Cells (Cell Line); Mice; Middle Aged; Phospholipids; metabolism; Pneumoconiosis; diagnosis; metabolism; physiopathology; Pulmonary Surfactant-Associated Protein A; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From: Biomedical and Environmental Sciences 2006;19(2):124-129
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the alterations of biomarkers in the development and progression of coal workers' pneumoconiosis (CWP).
METHODSThe type and number of cells, and the levels of tumor necrosis factor-alpha (TNF-alpha), pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1.
RESULTSCompared to active coal miners without CWP (8.23 microg/mL), TNF-alpha concentration was gradually decreased when dust exposure was stopped (5.90 microg/mL). Elevated surfactant protein A (SP-A) level and phosphatidylglycerol (PG) to phosphatidylinositol (PI) ratio were found in miners actively exposed to coal dust (6528 ng/mL for SP-A and 10. for PG/PI), and both parameters decreased when CWP progressed from CWP (0/1) (3419 microg/mL for SP-A and 5.9 for PG/PI) to CWP (1/1) (1654 microg/mL for SP-A and 5.5 for PG/PI).
CONCLUSIONBiomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers' pneumoconiosis.
