Association of-238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection.
- Author:
Hong-Quan LI
1
;
Zhuo LI
;
Ying LIU
;
Jun-Hong LI
;
Jian-Qun DONG
;
Ji-Rong GAO
;
Chun-Yan GOU
;
Hui LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; Haplotypes; Hepatitis B; genetics; physiopathology; Hepatitis B virus; pathogenicity; Hepatitis B, Chronic; genetics; physiopathology; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; genetics; Tumor Necrosis Factor-alpha; genetics
- From: Biomedical and Environmental Sciences 2006;19(2):133-136
- CountryChina
- Language:English
-
Abstract:
OBJECTIVESTo determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-alpha) gene promoter were associated with outcomes of hepatitis B virus infection.
METHODSA total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-alpha-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTSThe frequency of TNF-alpha-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P = 0.041). The frequency of TNF-alpha-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P = 0.021). Multiple logistic regression analysis revealed that both TNF-alpha-238GA and -857CC were independently associated with chronic HB.
CONCLUSIONSTNF-alpha promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection.
