In vitro anti-HIV activity of a Chinese fungus extract.
- Author:
Zi-Chun XIANG
1
;
Yan JIANG
;
Shun-Xing GUO
Author Information
- Publication Type:Journal Article
- MeSH: Anti-HIV Agents; pharmacology; Drugs, Chinese Herbal; pharmacology; Fungi; chemistry; HIV Infections; drug therapy; HIV-1; drug effects; genetics; Humans; Polymerase Chain Reaction; Time Factors; Transcription, Genetic; Virus Replication; drug effects
- From: Biomedical and Environmental Sciences 2006;19(3):169-172
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action.
METHODSSeveral in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1.
RESULTSM1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression.
CONCLUSIONThe target of M1 is post-integration of proviral DNA.
