Common SNPs of APM1 gene are not associated with hypertension or obesity in Chinese population.
- Author:
Wei-Li YAN
1
;
Shu-Feng CHEN
;
Jian-Feng HUANG
;
Yan SHEN
;
Bo-Qin QIANG
;
Dong-Hai LIU
;
Dong-Feng GU
Author Information
- Publication Type:Journal Article
- MeSH: Adiponectin; genetics; physiology; Alleles; Asian Continental Ancestry Group; genetics; Body Mass Index; Case-Control Studies; China; Haplotypes; Humans; Hypertension; complications; genetics; Lipids; blood; Lipoproteins, HDL; blood; Obesity; complications; genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; genetics; physiology; Population Groups; Waist-Hip Ratio
- From: Biomedical and Environmental Sciences 2006;19(3):179-184
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity (HO) and related clinical features in Chinese Han population.
METHODSA case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were genotyped by PCR product sequencing in 484 cases with HO and 502 controls with normal blood presure and BMI < 25.
RESULTSThe genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in T allele carriers than that in non-T carriers after adjusting possible confounding factors (1.21 vs 1.32 mmol/L, P=0.0001).
CONCLUSIONPolymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population. Common polymorphism of 45T/G might be associated with serum HDL-C levels in Chinese.
