In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.

Author: Fang HUANG ¹ ; Lin-Hua TANG ; Lin-Qian YU ; Yi-Chang NI ; Qin-Mei WANG ; Fa-Jun NAN
Author Information

1. National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. huangfang78@yahoo.com.cn
Publication Type:Journal Article
MeSH: Animals; Antimalarials; chemistry; pharmacokinetics; pharmacology; Plasmodium falciparum; drug effects; Umbelliferones; chemistry; pharmacokinetics; pharmacology
From: Biomedical and Environmental Sciences 2006;19(5):367-370
CountryChina
Language:English
Abstract:
OBJECTIVETo screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.
METHODPlasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.
RESULTSDA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.
CONCLUSIONThough the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.