When less is more: can we abandon prophylactic platelet transfusion in Dengue fever?
- Author:
Changa KURUKULARATNE
1
;
Frederico DIMATATAC
;
Diana Lt TEO
;
David C LYE
;
Yee Sin LEO
Author Information
1. Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
- Publication Type:Journal Article
- MeSH:
Dengue;
complications;
therapy;
Hemorrhage;
etiology;
prevention & control;
Humans;
Platelet Transfusion;
adverse effects;
economics;
Thrombocytopenia;
etiology;
prevention & control
- From:Annals of the Academy of Medicine, Singapore
2011;40(12):539-545
- CountrySingapore
- Language:English
-
Abstract:
Dengue fever (DF) has several hematological manifestations including thrombocytopenia and increased bleeding risk. Prophylactic platelet transfusion-in the absence of major bleeding-is utilized in DF with thrombocytopenia with the intention of preventing hemorrhagic complications. However, prophylactic platelet transfusion in DF is neither standardized nor supported by clinical evidence. We conclude that risks, costs and poor resource utilization associated with prophylactic platelet transfusion in DF far outweigh any potential hematological benefit, and as such, should not constitute routine clinical practice.
