Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial.

Jun GUO; Qing-He GAO; Fu WANG; Guo-Jin YU; Ji-Wei ZHANG; Yin ZENG; Qiang GENG; Bo-da GUO; Qiang HAN

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Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial.

Author: Jun GUO ¹ ; Qing-He GAO ¹ ; Fu WANG ² ; Guo-Jin YU ¹ ; Ji-Wei ZHANG ¹ ; Yin ZENG ¹ ; Qiang GENG ³ ; Bo-da GUO ⁴ ; Qiang HAN ⁵
Author Information

1. Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
2. Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. fu311306@163.com.
3. Department of Andrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
4. Xiangya School of Medicine, Central South University, Changsha, 410013, China.
5. Department of Andrology, Beijing Traditional Chinese Medicine Hospital Affilliated to Capital Medical University, Beijing, 100010, China.
Publication Type:Journal Article
Keywords: Chinese medicine; Qiaoshao Formula; dapoxetine; intra-vaginal ejaculation latency time; lifelong premature ejaculation; premature ejaculation diagnostic tool
MeSH: Adult; Drugs, Chinese Herbal; adverse effects; therapeutic use; Humans; Kidney; pathology; Liver; pathology; Male; Middle Aged; Personal Satisfaction; Premature Ejaculation; diagnosis; drug therapy; Syndrome; Time Factors; Treatment Outcome; Young Adult
From: Chinese journal of integrative medicine 2016;22(12):889-893
CountryChina
Language:English
Abstract:
OBJECTIVETo observe the effificacy and safety of Qiaoshao Formula (, QSF) on patients with lifelong premature ejaculation (LPE) of Gan (Liver) depression and Shen (Kidney) defificiency syndrome.
METHODSA total of 60 LPE patients were randomly divided into treatment (QSF) and control (dapoxetine) groups. The treatment group received QSF twice a day and the control group received dapoxetine 1 to 2 h prior to planned sexual intercourse for 4 weeks. The outcomes included intra-vaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), clinical global impression of change (CGIC), scores of Chinese medicine symptoms (CMSS), sex life satisfaction (SLS) and adverse events (AEs).
RESULTSIn the treated group, the median IELT was 3 min vs. 1.5 min before and after treatment (P<0.05). PEDT in the treated group was reduced to 11.76±1.68 from 15.83±2.30 after treatment (P<0.05). Besides, patient's SLS was improved from 1.30±0.05 to 6.30±0.04 (P<0.05), and spouse's SLS was increased from 1.30±0.to 6.10±0.06 (P<0.05); CMSS was decrease from 14.86±3.02 to 9.62±2.87 (P<0.05). In addition, no significant AE was observed in both groups.
CONCLUSIONQSF may be effective and safe on LPE patients with Gan depression and Shen defificiency syndrome.