Localized 1H-MR Spectroscopy in Moyamoya Disease before and after Revascularization Surgery.
- Author:
Soo Mee LIM
1
;
Hye Young CHOI
;
Jung Soo SUH
;
Jung Hee LEE
;
Keun Ho LIM
;
Dae Chul SUH
;
Ho Kyu LEE
;
Tae Hwan LIM
;
Young Shin RA
Author Information
- Publication Type:Original Article
- Keywords: Magnetic resonance (MR), spectroscopy; Brain, infarction; Moyamoya disease
- From:Korean Journal of Radiology 2003;4(2):71-78
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate, using localized proton magnetic resonance spectroscopy (1H-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease. MATERIALS AND METHODS: Sixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and 99mTc- ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized 1H-MRS, and after revascularization surgery, four patients underwent follow-up 1H-MRS. RESULTS: Decreased NAA/Cr ratios (1.35+/-0.14 in patients vs. 1.55+/-0.24 in controls) and Cho/Cr ratios (0.96+/-0.13 in patients vs. 1.10+/-0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios. CONCLUSION: Localized 1H-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, 1H-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring.
