Polymyositis as a manifestation of chronic graft-versus-host disease after allogeneic bone marrow transplantation.
- Author:
Hye Won LEE
1
;
Hee Kyung CHOI
;
Soo Jeong KIM
;
Doh Yu HWANG
;
Jun Yong CHOI
;
June Won CHEONG
;
Yoo Hong MIN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jwcheong70@yuhs.ac
- Publication Type:Case Report
- Keywords:
Graft vs. Host Disease;
Polymyositis
- MeSH:
Adult;
Biopsy;
Bone Marrow;
Bone Marrow Transplantation;
Creatine Kinase;
Early Diagnosis;
Fever;
Fructose-Bisphosphate Aldolase;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Humans;
Leukemia, Myeloid, Acute;
Muscle, Skeletal;
Muscles;
Myositis;
Necrosis;
Polymyositis;
Transplants
- From:Korean Journal of Medicine
2009;76(1):110-113
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Chronic graft-versus-host disease (cGVHD) remains one of the major complications of allogeneic hematopoietic stem cell transplantation. Although cGVHD has various manifestations in almost all organs, cases of cGVHD involving skeletal muscle are rare. We experienced a 26-year-old man with polymyositis with no other concurrent cGVHD after HLA-matched myeloablative transplantation for acute myelogenous leukemia. He had a history of acute and chronic GVHD. The patient complained of fever and myalgia 3 years after transplantation. The serum creatine kinase (CK, 2,223 IU/L) and aldolase (87.6 sigmaU/mL) were elevated. The muscle biopsy and electromyographic findings were consistent with myositis with necrosis. His condition improved dramatically with immunosuppressive therapy. Although muscle involvement, alone, in cGVHD is very rare, early diagnosis and proper treatment are still important.
