The effects of low dose doxycycline regimen on gingival crevicular fluid enzyme actmty of diabetic patients with periodontitis and adult periodontitis patients.
10.5051/jkape.1997.27.4.701
- Author:
Seong Nyum JEONG
1
;
Soo Boo HAN
Author Information
1. Department of Periodontology, School of Dentistry, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
low dose doxycycline;
collagenase;
elastase;
diabetics;
periodontitis;
root planing
- MeSH:
Adult*;
Chronic Periodontitis*;
Collagenases;
Dental Plaque;
Doxycycline*;
Gingival Crevicular Fluid*;
Humans;
Inflammation;
Pancreatic Elastase;
Periodontal Diseases;
Periodontitis*;
Root Planing
- From:The Journal of the Korean Academy of Periodontology
1997;27(4):701-722
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It was reported that low dose doxycycline(LDD) regimen could inhibit pathologically elevated collagenase activity in the gingival crevicular fluid of petients with adult periodontitis without producing typical antibiotic side effects. The purpose of this study was to evaluate the effects of LDD regimen(20mg) administered during non-surgical therapy on clinical index and gingival crevicular fluid enzyme activity in diabetics who are at high risk for periodontal disease. Fortynine subjects having at least two sites with probing pocket depths greater than 4mm were selected. In this double-blind, placebo-controlled study, the patients were administered 20 mg doxycycline capsule or placebo capsule b.i.d. for 2 weeks. Clinical parameters of dental plaque, gingival inflammation, probing pocket depth and probing attachment level were assessed at week 0, 2, 4, and 8. Gingival crevicular fluid samples were collected at the same time to evaluate the activities of collagenase and elastase. Clinical parameters and elastase activity were significantly reduced in all groups compared to the baseline value after treatment. Significantly greater reduction in pocket depth and gain in attachment level was shown in the LDD-administered group compared to placebo group in both adult periodontitis and diabetic patients. Total collagenase activity was also reduced significantly in all groups after treatment, but the greater reduction was seen in the LDD-administered diabetics group compared to relevant placebo group(at 4, 8week). Significantly greater reduction in active collagenase activity was also seen in the LDDadministered group compared to placebo group in diabetic patients(at 2, 4, 8week). These results indicated that use of low dose doxycycline could be aueseful adjunct to instrumentation therapy in the management of diabetic patient with periodontitis as well as adult periodontitis patient.
