Slow-release local drug delivery effect of tetracycline loaded calcium sulfate.
10.5051/jkape.1997.27.4.751
- Author:
Sung Hee KIM
1
;
Seong Ho CHOI
;
Kyoo Sung CHO
;
Jung Kiu CHAI
;
Kwang Kyun PARK
;
Chong Kwan KIM
Author Information
1. Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Korea.
- Publication Type:Original Article
- Keywords:
calcium sulfate;
tetracycline;
slow-release local drug delivery tetracycline- ethylene vinyl acetate fiber
- MeSH:
Absorption;
Anti-Bacterial Agents;
Bacteria;
Calcium Sulfate*;
Calcium*;
Drug Delivery Systems;
Humans;
Periodontal Diseases;
Tetracycline*
- From:The Journal of the Korean Academy of Periodontology
1997;27(4):751-765
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Periodontal disease is a bacterially caused by disease. To remove plaque and bacteria, it has been necessary to prescribe chemical drug to patient to subjugate therapeutic unvalue by mechanical scaling. As a patient on a high dosage of the antibiotics to maintain the effective concentration may produce unfavorable side effects, this decase demands the Slow-release local drug delivery system. The object of the experiment is to study on the slow-release local drug delivery effects of calcium sulfate compounded with tetracycline that mainly used in periodontal disease. Experimental groups were divided into four classes as follow: Group 1 : 10% tetracycline compounded modified calcium sulfate paste. Group 2 : compounded and hardened 10% tetracycline and calcium sulfate. Group 3 : compounded 10% tetracycline and calcium sulfate, used just before hardened. Group 4 : tetracycline-ethylene vinyl acetate fiber. In the four groups, release concentration, it's durability and the period of absorption by times are observed and concluded as follow: 1. An effective concentration(4microgram/ml) remained until 5 weeks in group 1, 9 days in group 2, 7 days in group 3, 15 days in group 4. 2. It was fully fused at 11.8 days average in group 2 and 14.8 days average in group 3. 3. There were no statistically significant results in tetracycline concentration until a week in group 2 and 3(p<0.05) These results suggest that tetracycline loaded calcium sulfate release sufficient tetracycline and fused in 11~14 days, so calcium sulfate is useful carrier as slow release local drug delivery system
