Malignant Transformation of Benign Giant Cell Tumor.
10.5292/jkbjts.2012.18.1.14
- Author:
Chang Bae KONG
;
Yun Suk HONG
;
Kwang Youl LEE
;
Sang Hyun CHO
;
Won Seok SONG
;
Wan Hyeong CHO
;
Jae Soo KOH
;
Dae Geun JEON
- Publication Type:Original Article
- Keywords:
giant cell tumor;
malignant transformation;
osteosarcoma
- MeSH:
Femur;
Follow-Up Studies;
Giant Cell Tumor of Bone;
Giant Cell Tumors;
Giant Cells;
Humans;
Lung;
Neoplasm Metastasis;
Osteosarcoma;
Radius;
Recurrence;
Referral and Consultation
- From:The Journal of the Korean Bone and Joint Tumor Society
2012;18(1):14-19
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We analyzed the oncologic outcome of the malignant transformed benign giant cell tumor of bone. MATERIALS AND METHODS: Between January 2000 and February 2012, 5 cases were referred with suspicious malignant transformation of benign giant cell tumor. No patients underwent radiation therapy. RESULTS: After referral, all patients received the wide excision of the tumor and its' pathologic diagnosis were osteosarcoma. As classified by the location of tumor lesion, 3 cases were located in the distal femur, 1 case was in the distal radius and 1 case was in the proximal femur. The average latent period between diagnosis of benign giant cell tumor and diagnosis of secondary malignant giant cell tumor was 49.2 months. (range, 24-126 months) The mean follow-up period was 21.6 months. There were subsequent local recurrence in 2 cases and 3 patients developed distant metastasis. All patients with lung metastasis were dead. CONCLUSION: Malignant transformation of benign giant cell tumor of bone can be occurred within 5 years. Therefore, when benign giant cell tumor suspicious malignant transformation, it is necessary to do more aggressive treatment.
