A Case of Radiation-Induced Pemphigus.
10.5021/ad.1998.10.3.212
- Author:
Min Soo LEE
;
Sung Moon JUNG
;
Jung Ho YOON
;
Gwang Yeol JOH
;
Soo Chan KIM
;
Ki Ho KIM
- Publication Type:Case Report
- Keywords:
Radiation-induced pemphigus;
Immunoblot
- MeSH:
Cytochrome P-450 CYP1A1;
Drug Therapy;
Humans;
Immunoblotting;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
Neck;
Pemphigus*;
Prednisolone;
Radiotherapy;
Rare Diseases;
Skin;
Thorax;
Upper Extremity
- From:Annals of Dermatology
1998;10(3):212-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
Radiation induced pemphigus, as an example of induced pemphigus, is a rare disease which occurs in patients receiving radiotherapy. A 56-year-old male patient with nasopharyngeal cancer received 3 cycles of chemotherapy and radiotherapy on the neck and anterior chest areas. One month after completion of radio-therapy, eroded and crusted areas developed within the irradiation site. In spite of systemic antibiotic treatment, the skin lesions persisted and spread further to the trunk and upper extremities with new crops of bullae. He was treated with a high dose of prednisolone and the skin lesions cleared. We discuss the suggestive pathogenesis of radiation-induced pemphigus with the comparative results of immunoblotting in various variants of pemphigus.
