Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita.
10.3349/ymj.1998.39.4.339
- Author:
Heun Jung CHO
1
;
Il Joo LEE
;
Soo Chan KIM
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. Kimsc@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
EBA;
complement-fixing ability;
IgG subclasses
- MeSH:
Adult;
Autoantibodies/classification*;
Complement/immunology*;
Epidermolysis Bullosa Acquisita/immunology*;
Female;
Fluorescent Antibody Technique;
Human;
IgG/classification*;
Male;
Middle Age
- From:Yonsei Medical Journal
1998;39(4):339-344
- CountryRepublic of Korea
- Language:English
-
Abstract:
Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
